Custom charcoal cover made for TMEM106B Cell publication by Stijn Vandebril.

For our recent publication “Identification of TMEM106B as a receptor mediating ACE2-independent SARS-CoV-2 cell entry” published in Cell, artist Stijn Vandebril made a stunning custom charcoal cover.
http://www.stijnvandebril.be/#

Team day Daelemans Lab 2023.

Today, the Daelemans Lab visited the Achouffe brewery, followed by a paintball session.

Ruth presenting her research on the ALT-pathway at the International Telomeres and Telomerases Conference at CSHL, New York.

Ruth, a PhD student in our lab, has attended the Telomeres and Telomerases meeting at the Cold Spring Harbor Laboratory, based in New York. Here she presented her research focusing on the target identification for the Alternative Lengthening of Telomeres (ALT) pathway.

E3 ubiquitin ligase ASB8 promotes selinexor-induced proteasomal degradation of XPO1.

Nucleocytoplasmic transport meets CRISPR screening. We performed CRISPR screens to identify genes that affect selinexor sensitivity. We establish that our main hit, ASB8, is responsible for selinexor-induced degradation of XPO1. Additionally, we suggest that TGFβ-SMAD signaling may predict clinical benefit from selinexor treatment in patients with multiple myeloma.