January 31, 2023

E3 ubiquitin ligase ASB8 promotes selinexor-induced proteasomal degradation of XPO1.

Nucleocytoplasmic transport meets CRISPR screening. We performed CRISPR screens to identify genes that affect selinexor sensitivity. We establish that our main hit, ASB8, is responsible for selinexor-induced degradation of XPO1. Additionally, we suggest that TGFβ-SMAD signaling may predict clinical benefit from selinexor treatment in patients with multiple myeloma.

More news

New publication in Nature Chemical Biology

Our latest work has just been published in Nature Chemical Biology:
SINE compounds activate exportin 1 degradation through an

November 21, 2025

✨Great news!✨

We are delighted to share that our PhD student Brecht Permentier has been granted a PhD Strategic Basic Research fellowship

October 3, 2025

We welcome Lore Willem to our lab as a new PhD student

After successfully defending her master’s thesis in our lab, Lore graduated as a bioscience engineer. Her Msc thesis was nominated

October 1, 2025

Ibetazol, a novel inhibitor of importin β1-mediated nuclear import.

Our research group has identified a series of compounds that trigger cytoplasmatic accumulation of importin α1. The lead compound, ibetazol,

November 23, 2024